Endocrine Abstracts

Dopamine agonists (DA), mainly cabergoline, are nowadays recommended as the treatment of choice for patients with prolactinomas of any size to lower PRL levels, decrease tumour size, and restore gonadal function. However, some patients do not adequately respond to DA, and resistance to DA may occur in 20-30% of patients treated with bromocriptine and nearly 10-20% of those receiving cabergoline. In these patients, multimodal therapy, including surgery and/or radiotherapy, may ...

Antithyroid drugs frequently used in management of hyperthyroidism may lead to liver damage. Hepatotoxicity is a rare but potentially fatal complication. The aim of this study was to present two cases of severe liver damage and the role of 131-I treatment in such cases.Case 1: A women 49 years of age with Graves hyperthyroidism was treated with metimazol (30 mg next 10 mg). After 1 month the utricarial skin rush was observed and the drug was changed to P...

Introduction: Femoral head avascular necrosis is a dangerous complication that can occur during glucocorticoid therapy, its frequency having been counted up to 40% of patients using corticoids. Even though the complete mechanism involved in this steroid-induced injury is not completely elucidated, studies have shown there’s some relation to bone remodelling, bone vasculature disfunction and apoptosis. We report here a case of femoral osteonecrosis associated to a very low...

Introduction: Fructosemia is a rare autosomal recessive genetic metabolic disorder, caused by mutations in the ALDOB (9q22.3) gene, encoding the enzyme aldolase B. This case shows that fructosemia typically causes hypoglycemia. This disorder should be included in differential diagnosis. Prevalence of GDM in women with fructosemia is unknown, but it is a rare condition1.Case: Five month old female baby arrived in 1976 to the Hospital o...

Introduction: Giant prolactinomas are rare tumours, they represent range from 0.5 to 4.0% of all pituitary tumours. We are presenting a patient with giant prolactinoma without visual field defects and any obvious clinical symptoms related to hyperprolactinemia and probably associated with alopecia universalis.Case: 32 years old man has visited outpatient department of our hospital, complaining of severe headache for the last three years. He underwent bra...

Di George syndrome is, in 93% of cases, the result of spontaneous mutations within the chromosome 22. Environmental factors may affect its occurrence. Phenotypic characteristics of Di George syndrome in children of alcohol-abusing or treated with izotretionin mothers were described. The case of a baby with Di George sndrome born to a woman with symptomatic hyperparathyroidism during her pregnancy is presented.Case report: A 30-year-old woman at 27 weeks ...

Aim of the study: To examine offspring of patients with simple obesity. To ascertain, if there are some disturbances in the carbohydrate or lipid metabolism or unknown type 2 diabetes in these subjects.Method and subjects: Examined were 132 families, 108 families with obesity, and 24 families without obesity, the control group. Fourteen additional were excluded because of ascertained at the time of examination unknown type 2 diabetes in the parents. In a...

Hypertension remains one of the most common diseases affecting more than 25% of the whole population. It is associated with high mortality risk due to cardiovascular complications. Usually hypertension is of idiopathic origin, however, several other diseases, including hormonal abnormalities may cause hypertension.Here, we present the frequency of primary hyperaldosteronism in a group of 310 hypertensive patients.Previously, they h...

Carney’s triad is a very rare syndrome, which comprises three tumors of different origin: gastrointestinal stromal tumor (GIST), thoracic chondroma and extraadrenal pheochromocytoma. It is found mainly in young female patients with blood group A. Two of the tumors need to be present for the diagnosis.Here we present the case of a 58-year-old male with blood group B. In July 2004 patient underwent resection of a part of small intestine with two GISTs...

Introduction: Intravenous methylprednisolon pulses (IVMP) are commonly accepted treatment in Graves orbitopathy (GO) However acute and severe liver damage has been reported in sporadic cases during such therapy. The aim of this study was to present the cases of severe liver damage after second and third course of IVMP.Case report: The white women 60 years of age with Graves disease diagnosed in 1983. Firstly she was treated with antythyroid drugs for 2 y...